ML251

Names

[ Name ]:
ML251

[Synonym ]:
Benzeneacetamide, 3,4-dichloro-N-[4-[(3-isoxazolylamino)sulfonyl]phenyl]-

Biological Activity

[Description]:

ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 0.37 μM (T. brucei PFK)[1]. IC50: 0.13 μM (T. cruzi PFK)[1]

[In Vitro]

ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1]. Cell Cytotoxicity Assay[1] Cell Line: T. brucei Concentration: 0~33.3 μg/mL Incubation Time: Result: Dose-dependent reduction of cell viability.

[References]

[1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₁₃Cl₂N₃O₄S

[ Molecular Weight ]:
426.27

[ Exact Mass ]:
425.000366

[ LogP ]:
3.61

[ Index of Refraction ]:
1.669

Related Compounds

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