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Hematoporphyrin monomethyl ether

Names

[ CAS No. ]:
148471-91-4

[ Name ]:
Hematoporphyrin monomethyl ether

[Synonym ]:
HeMatoporphyrinMonoMethylether
21H,23H-Porphine-2,18-dipropanoic acid, 7-(1-hydroxyethyl)-12-(1-methoxyethyl)-3,8,13,17-tetramethyl-
3,3'-[7-(1-Hydroxyethyl)-12-(1-methoxyethyl)-3,8,13,17-tetramethyl-2,18-porphyrindiyl]dipropanoic acid
Hematoporphyrinmonomethyl Ether

Biological Activity

[Description]:

Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and treatment of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Hematoporphyrin monomethyl ether (HMME) is a novel and promising porphyrin-related photosensitizer for photodynamic therapy (PDT). HMME-PDT can induce cell deaththrough both necrosis and apoptosis in HeLa cells. ROS, such as singlet oxygen and hydroxyl radical, generated in HeLa cells play a decisive role in HMME-PDT-induced cell death[2].

[References]

[1]. Ding X, et al. Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation. Cancer Lett. 2004;216(1):43-54.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1123.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H40N4O6

[ Molecular Weight ]:
612.715

[ Flash Point ]:
633.3±34.3 °C

[ Exact Mass ]:
612.294800

[ PSA ]:
160.36000

[ LogP ]:
6.87

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds