UDM-001651

Names

[ Name ]:
UDM-001651

Biological Activity

[Description]:

UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)

[Target]

IC50: 4 nM (PAR4)[1] Kd: 1.4 nM (PAR4)[1]

[References]

[1]. Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₃N₃O₅S

[ Molecular Weight ]:
513.56

Related Compounds

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