TAK-915

Names

[ Name ]:
TAK-915

[Synonym ]:
Pyrido[2,3-b]pyrazine-4(1H)-carboxamide, N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-2,3-dihydro-7-methoxy-2-oxo-
N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide

Biological Activity

[Description]:

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM; dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms; robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats. Schizophrenia Phase 1 Clinical

[References]

References 1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702. View Related Products by Target Phosphodiesterase (PDE) Schizophrenia

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
651.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₈F₄N₄O₅

[ Molecular Weight ]:
458.364

[ Flash Point ]:
347.5±31.5 °C

[ Exact Mass ]:
458.121338

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.539

Related Compounds

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