ID 8

Names

[ Name ]:
ID 8

[Synonym ]:
1-(4-Methoxy-phenyl)-2-methyl-3-nitro-1H-indol-6-ol
1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-
ID-8
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol
ID8

Biological Activity

[Description]:

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.IC50 Value: Target: DYRKin vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2]. In vivo:

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

Research Areas >> Cancer

[References]

[1]. Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1(1): p. 18-28.

[2]. Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72(5): p. 1242-8.

[Related Small Molecules]

Harmine | AZ 191 | TC-S 7004 | Protein kinase inhibitors 1 | EHT 5372

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
418.3±45.0 °C at 760 mmHg

[ Melting Point ]:
266 °C(dec.)

[ Molecular Formula ]:
C₁₆H₁₄N₂O₄

[ Molecular Weight ]:
298.293

[ Flash Point ]:
206.8±28.7 °C

[ Exact Mass ]:
298.095367

[ PSA ]:
80.21000

[ LogP ]:
4.13

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.638

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Validation of Perfusion Quantification with 3D Gradient Echo Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Blood Pool Contrast Agent in Skeletal Swine Muscle.

PLoS ONE 10 , e0128060, (2015)

The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood ...

Related Compounds

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