5'-DMT-2'-F-dU

Names

[ Name ]:
5'-DMT-2'-F-dU

[Synonym ]:
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine
DMT-2'-F-dU
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-
HG1172
5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine
5'-DMT-2'-F-dU

Biological Activity

[Description]:

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Filovirus

[In Vitro]

2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concen-trations up to 20 mM[1].

[References]

[1]. Christopher McGuigan, et al. Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues. ChemistryOpen. 2016 Jan 21;5(3):227-35.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₃₀H₂₉FN₂O₇

[ Molecular Weight ]:
548.559

[ Exact Mass ]:
548.195862

[ PSA ]:
112.01000

[ LogP ]:
4.83

[ Appearance of Characters ]:
Powder | White to Pale Yellow

[ Index of Refraction ]:
1.647

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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