Y-29794 oxalate

Names

[ Name ]:
Y-29794 oxalate

[Synonym ]:
(2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropyl-3-pyridinyl)(2-thienyl)methanone ethanedioate (1:1)
Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, ethanedioate (1:1)
(2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropylpyridin-3-yl)(2-thienyl)methanone ethanedioate (1:1)

Biological Activity

[Description]:

Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM)[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Perez RE, et al. Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Nov 1;21(11):1033-1040.

[2]. Kato A, et al. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35.

[3]. Nakajima T, et al. Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141(2):156-60.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₆N₂O₅S₂

[ Molecular Weight ]:
508.69

[ Exact Mass ]:
508.206573

Related Compounds

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