DETA-NONOate

Names

[ Name ]:
DETA-NONOate

[Synonym ]:
1,1-Bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
N-[bis(2-aminoethyl)amino]-N-hydroxynitrous amide
MFCD00278808
Diethylenetriamine nitric oxide adduct
DETA NONOate
2,2'-(hydroxynitrosohydrazono)bis-ethanamine
Ethanamine, 2,2'-(2-hydroxy-3-oxotriazanylidene)bis-

Biological Activity

[Description]:

NOC 18 is a nitric oxide donor and activates an inward current in cultured rat cerebellar granules cells. NOC 18 increases cGMP production in cultured vascular smooth muscle cells. NOC 18 reduces contractility of cardiac muscle preparations in vitro.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
303.0±52.0 °C at 760 mmHg

[ Melting Point ]:
98-106ºC

[ Molecular Formula ]:
C₄H₁₃N₅O₂

[ Molecular Weight ]:
163.178

[ Flash Point ]:
137.1±30.7 °C

[ Exact Mass ]:
163.106918

[ PSA ]:
108.18000

[ LogP ]:
-1.65

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: >20 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
KH2502500

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

In vivo imaging of reactive oxygen species in mouse brain by using [3H]hydromethidine as a potential radical trapping radiotracer.

J. Cereb. Blood Flow Metab. 34(12) , 1907-13, (2014)

To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential o...

Regulation of microglial migration, phagocytosis, and neurite outgrowth by HO-1/CO signaling.

Dev. Neurobiol. 75 , 854-76, (2015)

Clearance of infected and apoptotic neuronal corpses during inflammatory conditions is a fundamental process to create a favorable environment for neuronal recovery. Microglia are the resident immune ...

Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase.

Pflugers Arch. 466(10) , 1999-2008, (2014)

Soluble guanylyl cyclase (sGC), phosphodiesterase type 5 (PDE5), and guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) are all dimeric. The present study was to determine the ...