Phenylalanine,4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
Names
[ CAS No. ]:
1465-26-5
[ Name ]:
Phenylalanine,4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
[Synonym ]:
Dl-alanine,3-(p-[bis(2-chloroethyl)amino]phenyl)-,hydrochloride
MELPHALAN raceMic Mixture
4-[bis-(2-chloro-ethyl)-amino]-DL-phenylalanine,hydrochloride
Dl-phenylalanine,4-[bis(2-chloroethyl)amino]-,monohydrochloride
sarcolysine
4-[bis(2-chloroethyl)amino]-DL-phenylalanine monohydrochloride
Alanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-,hydrochloride,DL
Dl-phenylalanine mustard hydrochloride
Alanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-,monohydrochloride,DL
4-[Bis-(2-chlor-aethyl)-amino]-DL-phenylalanin,Hydrochlorid
Chemical & Physical Properties
[ Molecular Formula ]:
C13H19Cl3N2O2
[ Molecular Weight ]:
341.66100
[ Exact Mass ]:
340.05100
[ PSA ]:
66.56000
[ LogP ]:
3.42730
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY3980000
- CHEMICAL NAME :
- Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride, DL
- CAS REGISTRY NUMBER :
- 1465-26-5
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C13-H18-Cl2-N2-O2.Cl-H
- MOLECULAR WEIGHT :
- 341.69
- WISWESSER LINE NOTATION :
- QVYZ1R DN2G2G &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16200 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intratracheal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 44600 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 430 ug/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - thrombocytopenia Blood - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 860 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - leukopenia Blood - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41600 ug/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 mg/m3/2H/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in spleen Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 66 mg/kg/1Y-I
- TOXIC EFFECTS :
- Blood - changes in spleen Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- DOSE/DURATION :
- 1200 umol/L
- REFERENCE :
- BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 92,943,1981
Safety Information
[ HS Code ]:
2923900090
Customs
[ HS Code ]: 2923900090
[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%