Mal-NH2 TFA

Names

[ Name ]:
Mal-NH2 TFA

[Synonym ]:
Acetic acid, 2,2,2-trifluoro-, compd. with 1-(2-aminoethyl)-1H-pyrrole-2,5-dione (1:1)
MFCD01073617
N-(2-Aminoethyl)maleimide trifluoroacetic acid salt
1-(2-aminoethyl)pyrrole-2,5-dione,2,2,2-trifluoroacetic acid
1-(2-Aminoethyl)-1H-pyrrole-2,5-dione trifluoroacetate (1:1)
2-Maleimidoethylamine trifluoroacetate salt
N-(2-AMINOETHYL)MALEIMIDETRIFLUOROACETA

Biological Activity

[Description]:

Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Boiling Point ]:
278.1ºC at 760 mmHg

[ Melting Point ]:
124ºC

[ Molecular Formula ]:
C₈H₉F₃N₂O₄

[ Molecular Weight ]:
254.163

[ Flash Point ]:
122ºC

[ Exact Mass ]:
254.051437

[ PSA ]:
100.70000

[ LogP ]:
0.14160

[ Vapour Pressure ]:
0.00436mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2925190090

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

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