RUSKI-201

Names

[ Name ]:
RUSKI-201

[Synonym ]:
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-
2-[(2-Methylbutyl)amino]-1-[4-(6-methyl-2-pyridinyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]ethanone

Biological Activity

[Description]:

A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.

[References]

References 1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. View Related Products by Target Hedgehog (Hh)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
520.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₇N₃OS

[ Molecular Weight ]:
357.513

[ Flash Point ]:
268.7±30.1 °C

[ Exact Mass ]:
357.187469

[ LogP ]:
3.26

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.576

RUSKI-201

Names

Biological Activity

Chemical & Physical Properties

Related Compounds