BRD-7880

Names

[ Name ]:
BRD-7880

Biological Activity

[Description]:

A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM); is far more selective than tozasertib (VX-680), substantially inhibiting (to < 25% control activity) only AURKB and AURKC in a panel of 308 kinases.

[References]

References 1. Yu C, et al. Nat Biotechnol. 2016 Apr;34(4):419-23. View Related Products by Target Aurora Kinase

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₈N₄O₇

[ Molecular Weight ]:
590.677

Related Compounds

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