DRP1i27

Names

[ Name ]:
DRP1i27

Biological Activity

[Description]:

DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Cytoskeleton >> Dynamin

[In Vitro]

DRP1i27 (0-50 µM) 直接结合并抑制人 Drp1 的 GTPase 活性[1]。 DRP1i27 (0-50 µM) 能够以 Drp1 依赖性方式增加人和小鼠成纤维细胞中线粒体的细胞网络[1]。 DRP1i27 在 SPR 分析中的结合亲和力为 286 µM，在 MST 分析中的 KD 值为 190 µM[1]。

[References]

[1]. Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₆N₆O

[ Molecular Weight ]:
366.46

Related Compounds

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