CALP1 TFA

Names

[ Name ]:
CALP1 TFA

[Synonym ]:
VAL-ALA-ILE-THR-VAL-LEU-VAL-LYS
V-A-I-T-V-L-V-K
Calcium-like peptide 1
H-VAL-ALA-ILE-THR-VAL-LEU-VAL-LYS-OH
CALP
PEPTIDE MIMETIC OF CALCIUM
CALCIUM-LIKE PEPTIDE

Biological Activity

[Description]:

CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> mGluR

[Target]

Kd: 88 µM (Calmodulin)[4]

[References]

[1]. R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7.

[2]. R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3.

[3]. M K Manion, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306.

[4]. M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₇₅N₉O₁₀

[ Molecular Weight ]:
842.07800

[ Exact Mass ]:
841.56400

[ PSA ]:
313.27000

[ LogP ]:
3.51870

Related Compounds

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