SLP7111228 (hydrochloride)

Names

[ Name ]:
SLP7111228 (hydrochloride)

[Synonym ]:
1-Pyrrolidinecarboximidamide, 2-[[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-, (2S)-, hydrochloride (1:1)
(2S)-2-{[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-1-pyrrolidinecarboximidamide hydrochloride (1:1)

Biological Activity

[Description]:

SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with Ki values of 0.048 and >10 ��M for SPHK1 and 2, respectively.

[In Vitro]

SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with Ki values of 0.048 and >10 ��M for SPHK1 and 2, respectively.It induces a concentration-dependent decrease in sphingosine-1-phosphate in U937 cells but has no effect on sphingosine levels. In vivo, SLP7111228 decreases blood levels of S1P in a dose-dependent manner in rats.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₃N₅O_.HCl

[ Molecular Weight ]:
419.991

[ Exact Mass ]:
419.245178

Related Compounds

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