HJC 0726

HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM; also inhibits EPAC1-mediated Rap1-GDP exchange activity; does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM; inhibits GEF activity of the full-length EPAC1 in the presence of 20 µM cAMP with IC50 of 2.4 uM.

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