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m-PEG6-NHS ester

Names

[ CAS No. ]:
1449390-12-8

[ Name ]:
m-PEG6-NHS ester

[Synonym ]:
1-[(20-Oxo-2,5,8,11,14,17-hexaoxaicosan-20-yl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13,16,19-hexaoxaeicos-1-yl)oxy]-
mPEG5-NHS

Biological Activity

[Description]:

m-PEG6-NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Boehnke, Niels, et al. Preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer. Patent WO2019149637.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
502.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H31NO10

[ Molecular Weight ]:
421.439

[ Flash Point ]:
257.8±32.9 °C

[ Exact Mass ]:
421.194794

[ LogP ]:
-3.59

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.489

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds