Amgen-23

Names

[ Name ]:
Amgen-23

Biological Activity

[Description]:

Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> SPHK

[Target]

SphK1:20 nM (IC50)

SphK2:1.6 μM (IC50)

[References]

[1]. Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₅Cl₂N₃O₂S

[ Molecular Weight ]:
478.43

[ Storage condition ]:
-20°C

Related Compounds

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