Desoxycarbadox-D3

Names

[ Name ]:
Desoxycarbadox-D3

[Synonym ]:
Hydrazinecarboxylic acid, 2-(2-quinoxalinylmethylene)-, methyl-d3 ester, (2E)-
(2H3)Methyl (2E)-2-(2-quinoxalinylmethylene)hydrazinecarboxylate

Biological Activity

[Description]:

Desoxycarbadox-d3 is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. MacIntosh AI, et al. Liquid chromatographic monitoring of the depletion of carbadox and its metabolite desoxycarbadox in swine tissues. J Assoc Off Anal Chem. 1985;68(4):665-671.

[3]. Looft T, et al. Carbadox has both temporary and lasting effects on the swine gut microbiota. Front Microbiol. 2014;5:276. Published 2014 Jun 10.

[4]. Zhang K, et al. Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and compared with its metabolites. Environ Toxicol Pharmacol. 2015;39(2):555-567.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₁H₇D₃N₄O₂

[ Molecular Weight ]:
233.241

[ Exact Mass ]:
233.099213

[ LogP ]:
1.72

[ Index of Refraction ]:
1.634

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H302-H350

[ Precautionary Statements ]:
P201-P210-P308 + P313

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
R45-11-22

[ Safety Phrases ]:
S53-45

[ RIDADR ]:
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all

Related Compounds

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