MCT1-IN-4a

MCT1-IN-4a is a potent, selective monocarboxylate transporter 1 (MCT1) inhibitor with IC50 of 90 nM; exhibits significant single agent activity in MCT1 expressing GL261-luc2 syngraft model, but not in MCT4 expressing MDA-MB-231 xenograft model; has good absorption, metabolic stability, and a low drug efflux ratio.

References 1. Gurrapu S, et al. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3282-6. View Related Products by Target Monocarboxylate Transporter (MCT)