Binodenoson

Names

[ Name ]:
Binodenoson

[Synonym ]:
sha 174
wrc 0470
mre 0470
sha 211
binodenoson

Biological Activity

[Description]:

Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[In Vitro]

Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1].

[In Vivo]

Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage[1].

[References]

[1]. Sullivan GW, et al. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram. J Infect Dis. 1999;180(5):1550-1560.

[2]. Glover DK, et al. Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470). A novel, short-acting adenosine A2A receptor agonist. Circulation. 1996;94(7):1726-1732.

Chemical & Physical Properties

[ Density]:
1.76g/cm3

[ Boiling Point ]:
765.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₅N₇O₄

[ Molecular Weight ]:
391.42

[ Flash Point ]:
416.8ºC

[ Exact Mass ]:
391.19700

[ PSA ]:
163.93000

[ LogP ]:
0.65220

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.812

Related Compounds

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