Thielocin B1

Thielocin B1 is a protein-protein interaction inhibitor of PAC3 homodimer. Thielocin B1 was isolated as a novel phospholipase A2 inhibitor from the fermentation broth of Thielavia terricola RF-143.

1. Matsumoto K, Tanaka K, Matsutani S, Sakazaki R, Hinoo H, Uotani N, Tanimoto T, Kawamura Y, Nakamoto S, Yoshida T. Isolation and biological activity of thielocins: novel phospholipase A2 inhibitors produced by Thielavia terricola RF-143. J Antibiot (Tokyo). 1995 Feb;48(2):106-12. PubMed PMID: 7706119.