Quininib

Names

[ Name ]:
Quininib

[Synonym ]:
2-[(E)-2-(2-Quinolinyl)vinyl]phenol
Quininib
2-[(E)-2-(Quinolin-2-yl)vinyl]phenol
2-[(E)-2-(quinolin-2-yl)ethenyl]phenol
Phenol, 2-[(E)-2-(2-quinolinyl)ethenyl]-
(E)-2-[2-(2-Quinolinyl)ethenyl]-phenol
MFCD00186931

Biological Activity

[Description]:

A potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively; demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis; does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems.

[References]

References 1. Reynolds AL, et al. J Biol Chem. 2016 Apr 1;291(14):7242-55. 2. Murphy AG, et al. Sci Rep. 2016 Oct 14;6:34523. 3. Galvin O, et al. J Control Release. 2016 Jul 10;233:198-207. 4. Butler CT, et al. J Biol Chem. 2017 Mar 3;292(9):3552-3567. View Related Products by Target Leukotriene Receptor

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
434.3±14.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₃NO

[ Molecular Weight ]:
247.291

[ Flash Point ]:
216.5±20.1 °C

[ Exact Mass ]:
247.099716

[ LogP ]:
4.72

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.758

Related Compounds

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