BR103

Names

[ Name ]:
BR103

Biological Activity

[Description]:

BR103 is a potent, metabolically stable and highly selective small molecule agonist of complement C3a receptor (C3aR) with EC50 of 22 ± 8 nM; displays high selectivity for C3aR over C5aR; induces paw oedema and mast cell activation in vivo in rats.

[References]

References 1. Lohman RJ, et al. Nat Commun. 2017 Aug 24;8(1):351. View Related Products by Target Complement System

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₈N₆O₃

[ Molecular Weight ]:
448.527