MK-8768

Names

[ Name ]:
MK-8768

Biological Activity

[Description]:

MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 .6nM) with excellent brain permeability.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Metabolic Disease

[Target]

IC50:9.6 nM(mGluR2)[1]

[References]

[1]. Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023，14，8.

[2]. Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂F₃N₅O₂

[ Molecular Weight ]:
433.43

Related Compounds

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