Tin-protoporphyrin IX
Names
[ CAS No. ]:
14325-05-4
[ Name ]:
Tin-protoporphyrin IX
[Synonym ]:
3,3'-[(1Z,6Z,12Z,17Z)-22,22-Dichloro-15,20-diethyl-5,9,14,19-tetramethyl-21,23,24,25-tetraaza-22-stannahexacyclo[9.9.3.1.1.0.0]pentacosa-1,3(25),4,6,8,10,12,14,16(24),17,19-un 
decaene-4,10-diyl]dipropanoic acid
tin protophorphyrin
Biological Activity
[Description]:
Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].
[Related Catalog]:
[Target]
IC50: Heme oxygenase-1 (HO-1)[1]
[In Vitro]
Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1]. Cell Viability Assay[1] Cell Line: Capan-1, CD18/HPAF, PDAC cells Concentration: 20 μM, 50 μM Incubation Time: 24 or 72 hours Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.
[In Vivo]
Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1]. Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
[References]
Chemical & Physical Properties
[ Boiling Point ]:
849.3±75.0 °C at 760 mmHg
[ Molecular Formula ]:
C34H32Cl2N4O4Sn
[ Molecular Weight ]:
754.290
[ Flash Point ]:
467.5±37.1 °C
[ Exact Mass ]:
754.113586
[ PSA ]:
109.18000
[ LogP ]:
4.75380
[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C
Precursor & DownStream