TASP 0433864

Names

[ CAS No. ]:
1431980-60-7

[ Name ]:
TASP 0433864

[Synonym ]:
MFCD30720884
(2S)-5-Methyl-2-{[4-(2-methyl-2-propanyl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide
Imidazo[2,1-b]oxazole-6-carboxamide, 2-[[4-(1,1-dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methyl-, (2S)-

Biological Activity

[Description]:

A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity; has negligible activities for other mGlu receptors, including mGlu3 receptor; potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram; significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice.

[References]

References 1. Hiyoshi T, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):642-53. View Related Products by Target mGluR

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
521.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₃N₃O₃

[ Molecular Weight ]:
329.393

[ Flash Point ]:
269.1±32.9 °C

[ Exact Mass ]:
329.173950

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds

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