[Asu1,6]-Oxytocin

Names

[ Name ]:
[Asu1,6]-Oxytocin

[Synonym ]:
tyr-ile-gln-asn-asu-pro-leu-gly-nh2

Biological Activity

[Description]:

[Asu1,6]-Oxytocin is an analog of oxytocin. [Asu1,6]-Oxytocin reverses insulin resistance and glucose intolerance prior to reduction of obesity. [Asu1,6]-Oxytocin has the potential for the research of obesity and diabetes[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

[Asu1,6]-Oxytocin (4 μg per injection; third-ventricle injection, twice injected for 7 days) 改善小鼠的葡萄糖耐受不良并降低空腹血胰岛素水平[1]。 Animal Model: C57BL/6 mice[1] Dosage: 4 μg per injection Administration: Third-ventricle injection, twice injected for 7 days Result: Improved glucose intolerance and lowered fasting blood insulin levels, and both effects were independent of body weight.

[References]

[1]. Zhang H, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One. 2013 May 20;8(5):e61477.

Chemical & Physical Properties

[ Density]:
1.216g/cm3

[ Boiling Point ]:
1475.3ºC at 760 mmHg

[ Molecular Formula ]:
C₄₅H₆₉N₁₁O₁₂

[ Molecular Weight ]:
956.09600

[ Flash Point ]:
846ºC

[ Exact Mass ]:
955.51300

[ PSA ]:
373.51000

[ LogP ]:
2.09780

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.531

Related Compounds

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