Isobutyl-deoxynyboquinone
Names
[ CAS No. ]:
1430798-22-3
[ Name ]:
Isobutyl-deoxynyboquinone
Biological Activity
[Description]:
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1), produces ROS, and induces cytotoxicity in cancer cells in an NQO1-dependent manner; has improved solubility and biocompatibility in comparison with DNQ; a superior drug candidate for evaluating anticancer activities and tolerability in vivo.
[References]
References 1. Parkinson EI, et al. Acc Chem Res. 2015 Oct 20;48(10):2715-23. 2. Lundberg AP, et al. Invest New Drugs. 2017 Apr;35(2):134-144. 3. Parkinson EI, et al. ACS Chem Biol. 2013 Oct 18;8(10):2173-83. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C18H18N2O4
[ Molecular Weight ]:
326.352
Related Compounds
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