DBCO-S-S-PEG3-Biotin

Names

[ Name ]:
DBCO-S-S-PEG3-Biotin

[Synonym ]:
N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[25-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-7,21-dioxo-11,14,17-trioxa-3,4-dithia-8,20-diazapentacos-1-yl]-γ-oxo-

Biological Activity

[Description]:

DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1194.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₅₆N₆O₈S₃

[ Molecular Weight ]:
869.124

[ Flash Point ]:
676.0±34.3 °C

[ Exact Mass ]:
868.332153

[ LogP ]:
3.12

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
-20°C

Related Compounds

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