OXF BD 02

Names

[ Name ]:
OXF BD 02

[Synonym ]:
Benzenemethanol, 3-(3,5-dimethyl-4-isoxazolyl)-5-hydroxy-α-phenyl-
3-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(phenyl)methyl]phenol

Biological Activity

[Description]:

OXF BD 02 is a selective inhibitor of BRD4(1) (the first bromodomain of BRD4) with IC50value of 382 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4(1):382 nM (IC50)

[References]

[1]. Hewings DS, et al. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013 Apr 25;56(8):3217-27.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
515.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₇NO₃

[ Molecular Weight ]:
295.33

[ Flash Point ]:
265.5±30.1 °C

[ Exact Mass ]:
295.120850

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.616

Related Compounds

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