YH16899

Names

[ Name ]:
YH16899

[Synonym ]:
3(2H)-Benzothiazoleacetic acid, α-ethyl-5,6-difluoro-2-[[3-(trifluoromethyl)benzoyl]imino]-, (2Z)-
2-[(2Z)-5,6-Difluoro-2-{[3-(trifluoromethyl)benzoyl]imino}-1,3-benzothiazol-3(2H)-yl]butanoic acid

Biological Activity

[Description]:

YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Kim DG, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014 Jan;10(1):29-34.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
569.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₃F₅N₂O₃S

[ Molecular Weight ]:
444.375

[ Flash Point ]:
298.4±32.9 °C

[ Exact Mass ]:
444.056702

[ LogP ]:
5.08

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds

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