NBD-11021

Names

[ Name ]:
NBD-11021

Biological Activity

[Description]:

A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). HIV Preclinical

[References]

References 1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927. View Related Products by Target HIV HIV

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₅ClN₄O₂S

[ Molecular Weight ]:
444.978

Related Compounds

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