5'-Trt-2'-dU

Names

[ Name ]:
5'-Trt-2'-dU

[Synonym ]:
1-[(2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5'-Trt-2'-dU

Biological Activity

[Description]:

5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Melting Point ]:
204-205 °C

[ Molecular Formula ]:
C₂₈H₂₆N₂O₅

[ Molecular Weight ]:
470.52

[ Exact Mass ]:
470.18400

[ PSA ]:
93.55000

[ LogP ]:
3.19370

[ Index of Refraction ]:
1.63

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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