ML298

Names

[ Name ]:
ML298

[Synonym ]:
3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide
Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-

Biological Activity

[Description]:

ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM); decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile, making it an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments.

[References]

References 1. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 2. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
650.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₃F₃N₄O₂

[ Molecular Weight ]:
432.439

[ Flash Point ]:
347.2±31.5 °C

[ Exact Mass ]:
432.177307

[ LogP ]:
1.70

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.620

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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