RB-005

Names

[ Name ]:
RB-005

[Synonym ]:
1-[2-(4-Octylphenyl)ethyl]-4-piperidinol
4-Piperidinol, 1-[2-(4-octylphenyl)ethyl]-

Biological Activity

[Description]:

RB-005 (RB-005) is a potent, selective inhibitor of sphingosine kinase SphK1 (SK1) with IC50 of 3.6 uM, displays 15-fold selectivity over SphK2.

[References]

References 1. Baek DJ, et al. Chem Commun (Camb). 2013 Mar 14;49(21):2136-8. 2. Baek DJ, et al. J Med Chem. 2013 Nov 27;56(22):9310-27. 3. MacRitchie N, et al. Cell Signal. 2016 Aug;28(8):946-55. View Related Products by Target Sphingosine kinase (SphK)

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
452.0±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₅NO

[ Molecular Weight ]:
317.509

[ Flash Point ]:
35.6±18.7 °C

[ Exact Mass ]:
317.271851

[ LogP ]:
5.61

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.524

Related Compounds

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