LY2922470

Names

[ Name ]:
LY2922470

[Synonym ]:
MFCD30489363
(3S)-3-[4-({5-[(8-Methoxy-3,4-dihydro-1(2H)-quinolinyl)methyl]-2-thienyl}methoxy)phenyl]-4-hexynoic acid
Benzenepropanoic acid, 4-[[5-[(3,4-dihydro-8-methoxy-1(2H)-quinolinyl)methyl]-2-thienyl]methoxy]-β-1-propyn-1-yl-, (βS)-

Biological Activity

[Description]:

LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduces glucose levels along with significant increases in insulin and GLP-1, is potential for the treatment of type 2 diabetes mellitus (T2DM)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40

Research Areas >> Metabolic Disease

[Target]

EC50：7 nM (human GPR40), 1 nM (mouse GPR40), 3 nM (rat GPR40)[1]

[References]

[1]. Hamdouchi C, et al. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). J Med Chem. 2016 Dec 22;59(24):10891-10916.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
689.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₂₉NO₄S

[ Molecular Weight ]:
475.599

[ Flash Point ]:
370.5±31.5 °C

[ Exact Mass ]:
475.181732

[ LogP ]:
5.89

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.626

Related Compounds

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