Cidofovir diphosphate

Names

[ CAS No. ]:
142276-31-1

[ Name ]:
Cidofovir diphosphate

Biological Activity

[Description]:

Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[Target]

Viral DNA polymerase[1]


[References]

[1]. Hitchcock MJM, et al. Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity. 1996.

[2]. Magee WC, et al. Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob Agents Chemother. 2005 Aug;49(8):3153-62.  

Chemical & Physical Properties

[ Molecular Formula ]:
C8H16N3O12P3

[ Molecular Weight ]:
439.15

Related Compounds