1-Boc-azetidine-3-carboxylic acid

Names

[ Name ]:
1-Boc-azetidine-3-carboxylic acid

[Synonym ]:
1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azetidinecarboxylic acid
1-N-Boc-3-Azetidinecarboxylic Acid
1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid
MFCD01860897
1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid
N-Boc-Azetidine-3-carboxylic acid
1-BOC-Azetidine-3-carboxylic acid
1-Boc-azetidine-3-carboxylicacid

Biological Activity

[Description]:

1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
321.0±35.0 °C at 760 mmHg

[ Melting Point ]:
100.1-101.9°C

[ Molecular Formula ]:
C₉H₁₅NO₄

[ Molecular Weight ]:
201.220

[ Flash Point ]:
147.9±25.9 °C

[ Exact Mass ]:
201.100113

[ PSA ]:
66.84000

[ LogP ]:
0.27

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.510

[ Storage condition ]:
Store at -15°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S22-S24/25-S37-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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