FD1024

Names

[ CAS No. ]:
1422456-47-0

[ Name ]:
FD1024

Biological Activity

[Description]:

FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[Target]

1.96, 38.9, 4.17 nM for PIM1, 2, 3[1]


[References]

[1]. Xiang R, et al. Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171. Eur J Med Chem. 2023 Sep 5;257:115514.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20F2N4O2S

[ Molecular Weight ]:
430.47

Related Compounds

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