TMP780

Names

[ CAS No. ]:
1422053-03-9

[ Name ]:
TMP780

Biological Activity

[Description]:

TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

[Target]

IC50: 13 nM (RORγt)[1]

[References]

[1]. Skepner J, et al. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₀N₂O₄

[ Molecular Weight ]:
494.58

Related Compounds

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