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Bromoacetamido-PEG3-NH-Boc

Names

[ CAS No. ]:
1421933-39-2

[ Name ]:
Bromoacetamido-PEG3-NH-Boc

[Synonym ]:
MFCD23378554
2-Methyl-2-propanyl (14-bromo-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)carbamate
Carbamic acid, N-(14-bromo-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
543.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H29BrN2O6

[ Molecular Weight ]:
413.305

[ Flash Point ]:
282.7±30.1 °C

[ Exact Mass ]:
412.120880

[ LogP ]:
0.45

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.484

Related Compounds