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S-Acetyl-PEG3-C2-acid

Names

[ CAS No. ]:
1421933-33-6

[ Name ]:
S-Acetyl-PEG3-C2-acid

[Synonym ]:
6,9,12-Trioxa-3-thiapentadecan-15-oic acid, 2-oxo-
2-Oxo-6,9,12-trioxa-3-thiapentadecan-15-oic acid
MFCD22574765

Biological Activity

[Description]:

S-Acetyl-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
421.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H20O6S

[ Molecular Weight ]:
280.338

[ Flash Point ]:
208.7±27.3 °C

[ Exact Mass ]:
280.098053

[ LogP ]:
-0.17

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.489

Related Compounds