L-3,4-Dihydroxyphenylalanine Methyl ester hydrochloride
Names
[ CAS No. ]:
1421-65-4
[ Name ]:
L-3,4-Dihydroxyphenylalanine Methyl ester hydrochloride
[Synonym ]:
L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride
MFCD00038958
L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride (1:1)
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate,hydrochloride
Methyl 3-hydroxy-L-tyrosinate hydrochloride (1:1)
(S)-Methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate hydrochloride
Methyl L-DOPA hydrochloride
methyldopa hydrochloride
Chemical & Physical Properties
[ Density]:
1.322g/cm3
[ Boiling Point ]:
384.4ºC at 760mmHg
[ Molecular Formula ]:
C10H14ClNO4
[ Molecular Weight ]:
247.676
[ Flash Point ]:
186.3ºC
[ Exact Mass ]:
247.061142
[ PSA ]:
92.78000
[ LogP ]:
1.64290
[ Vapour Pressure ]:
1.86E-06mmHg at 25°C
[ Storage condition ]:
-20°C
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2923900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2923900090
[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
PLoS ONE 9(9) , e106362, (2014)
L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transport...
L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.J. Neurosci. Res. 92(12) , 1733-45, (2014)
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is the most common complication of standard L-DOPA therapy for Parkinson's disease experienced by most parkinsonian patients. LID is asso...
Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia.Synapse 68(8) , 332-43, (2014)
l-3,4-Dihydroxyphenylalanine (L-DOPA) is the most widely used drug for the treatment of Parkinson's disease. Unfortunately, chronic administration of this dopamine precursor causes L-DOPA-induced dysk...