PR-924

Names

[ Name ]:
PR-924

[Synonym ]:
ZI5ZER54A9
D-erythro-3-Pentulose, 4,5-anhydro-1,2-dideoxy-4-C-methyl-2-[[N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-L-tryptophyl]amino]-1-phenyl-
PR-924
4,5-Anhydro-1,2-dideoxy-4-methyl-2-({N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-L-tryptophyl}amino)-1-phenyl-D-erythro-pent-3-ulose

Biological Activity

[Description]:

A potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM); shows weak activity toward LMP2 and no detectable activity toward β1, β2, or MECL1.

[References]

References 1. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
969.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₇H₃₈N₄O₅

[ Molecular Weight ]:
618.721

[ Flash Point ]:
539.8±34.3 °C

[ Exact Mass ]:
618.284241

[ LogP ]:
6.17

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.