4-Chloro-3-ethylphenol

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
248.1±20.0 °C at 760 mmHg

[ Melting Point ]:
45-50 °C(lit.)

[ Molecular Formula ]:
C₈H₉ClO

[ Molecular Weight ]:
156.609

[ Flash Point ]:
103.9±21.8 °C

[ Exact Mass ]:
156.034195

[ PSA ]:
20.23000

[ LogP ]:
3.42

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.555

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Click to get detail synthetic route

The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels.

Br. J. Pharmacol. 171(5) , 1250-9, (2014)

Depletion of the Ca(2+) store by ryanodine receptor (RyR) agonists induces store-operated Ca(2+) entry (SOCE). 4-Chloro-3-ethylphenol (4-CEP) and 4-chloro-m-cresol (4-CmC) are RyR agonists commonly us...

Superficial buffer barrier and preferentially directed release of Ca2+ in canine airway smooth muscle.

Am. J. Physiol. 276(5 Pt 1) , L744-53, (1999)

We examined cytosolic concentration of Ca2+ ([Ca2+]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca2+]i), membrane currents (subsarcolemmal [Ca2+]i), and contractions ...

Actions of 4-chloro-3-ethyl phenol on internal Ca2+ stores in vascular smooth muscle and endothelial cells.

Br. J. Pharmacol. 122(3) , 504-10, (1997)

1. Recently, 4-chloro-3-ethyl phenol (CEP) has been shown to cause the release of internally stored Ca2+ apparently through ryanodine-sensitive Ca2+ channels, in fractionated skeletal muscle terminal ...

More Articles