Microcolin B

Names

[ Name ]:
Microcolin B

[Synonym ]:
(2R,3S)-4-({N-[(2R,4R)-2,4-Dimethyloctanoyl]-N-methyl-L-leucyl}amino)-3-(methyl{(2S)-3-methyl-1-[(2S)-2-{[(2S)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}-1-pyrrolidinyl]-1-oxo-2-butanyl}amino)-4-oxo-2-butanyl acetate
Threoninamide,N-(2,4-dimethyl-1-oxooctyl)-N-methylleucyl-N-(1-((2-((2,5-dihydro-2-methyl-5-oxo-1H-pyrrol-1-yl)carbonyl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)-N-methyl-,acetate (ester)
Octanamide, N-[(1S)-1-[[[(2S,3R)-3-(acetyloxy)-2-[[(1S)-1-[[(2S)-2-[[(2S)-2,5-dihydro-2-methyl-5-oxo-1H-pyrrol-1-yl]carbonyl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]methylamino]-1-oxobutyl]amino]carbonyl]-3-methylbutyl]-N,2,4-trimethyl-, (2R,4R)-

Biological Activity

[Description]:

Microcolin B is an extremely potent unusual acylpeptide, proline-containing potent immunosuppressant. Microcolin B is isolated from blue-green alga Lyngbya majuscule[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. • Merritt B. Andrus, et al. Synthesis of Microcolin B, a Potent New Immunosuppressant Using an Efficient Mixed Imide Formation Reaction. J. Org. Chem. 1997, 62, 16, 5542–5549.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
835.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₉H₆₅N₅O₈

[ Molecular Weight ]:
731.962

[ Flash Point ]:
459.3±34.3 °C

[ Exact Mass ]:
731.483337

[ PSA ]:
157.20000

[ LogP ]:
5.26

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.516

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.