<Suppliers Price>

Lademirsen

Names

[ CAS No. ]:
1404019-95-9

[ Name ]:
Lademirsen

Biological Activity

[Description]:

Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21. Lademirsen has the potential for Alport nephropathy research[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> MicroRNA
Research Areas >> Inflammation/Immunology

[In Vivo]

Administration of Lademirsen (SAR339375; RG-012) to inhibit miR-21 leads to a slowed progression of renal fibrosis and an increased lifespan in Alport syndrome mouse models[1].

[References]

[1]. Ivan G Gomez, et al. Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J Clin Invest. 2015 Jan;125(1):141-56.

[2]. Chiranjib Chakraborty, et al. Therapeutic advances of miRNAs: A preclinical and clinical update. J Adv Res. 2020 Aug 29;28:127-138.

Chemical & Physical Properties

No Any Chemical & Physical Properties