CORT 118335

Names

[ Name ]:
CORT 118335

[Synonym ]:
6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-(4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]-

Biological Activity

[Description]:

CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.

[In Vitro]

CORT 118335 (Miricorilant, C118335)?is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₂₃F₃N₂O₂

[ Molecular Weight ]:
428.447

[ Exact Mass ]:
428.171173

[ LogP ]:
6.21

[ Index of Refraction ]:
1.562

Related Compounds

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