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MRL-871

Names

[ CAS No. ]:
1392809-08-3

[ Name ]:
MRL-871

Biological Activity

[Description]:

MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR
Research Areas >> Cancer

[In Vitro]

MRL-871 (compound 3; 10 μM, 24h) significantly reduces IL-17a mRNA expression 48-fold in EL4 cells[1].

[References]

[1]. Meijer FA, et, al. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists. J Med Chem. 2020 Jan 9;63(1):241-259.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H12ClF3N2O3

[ Molecular Weight ]:
444.7904896

Related Compounds